Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania

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Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania

Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical severity in sickle cell disease (SCD), while reticulocytosis is associated with vasculopathy, but there are few data on mechanisms. HbF, SpO2 and routine clinical and laboratory measures were available in a Tanzanian cohort of 1175 SCD individuals aged≥5years and the association with SpO2 (as respons...

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Clinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease

Article history: Received 3 September 2017 Accepted 3 September 2017 Available online 5 September 2017 inhibition of HbS polymerization—and therefore remain key topics of investigation and continued interest in the field. The current report by Nkya et al. (Nkya et al., 2017) shows associations between HbF, hemoglobin, pulse rate and systolic blood pressure with peripheral oxygen saturation in a...

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Pulse oximetry and factors associated with hemoglobin oxygen desaturation in children with sickle cell disease.

The observation of low transcutaneous arterial oxygen saturation (SaO2) in otherwise well sickle cell patients has lead to questions about the interpretation of pulse oximetry values in these patients. We undertook a prospective study of children with sickle cell disease to (1) determine the prevalence of, and factors associated with, low transcutaneous SaO2 in clinically well patients, (2) dev...

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Induction of fetal hemoglobin in sickle cell disease.

THIS ISSUE OF BLOOD features a report by Atweh et al1 on the induction of fetal hemoglobin (Hb F) by pulse butyrate. This study is a solid addition to the recent and gratifying momentum in the development of effective therapy for sickle cell disease. Underlying this report is a series of novel and convincing in vivo studies extending from model systems in the chicken,2 sheep,3 and baboons4-6 to...

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Fetal hemoglobin in sickle cell anemia

Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable. Some patients with sickle cell disease have exceptionally high level...

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ژورنال

عنوان ژورنال: EBioMedicine

سال: 2017

ISSN: 2352-3964

DOI: 10.1016/j.ebiom.2017.08.006